The Chang Lab of Quantitative Molecular Biology is a vibrant research lab affiliated with the Interdisciplinary Program in Bioinformatics and School of Biological Sciences at Seoul National University, Korea. We aim to understand how the gene expression is regulated post-transcriptionally by the interactions between biological molecules in a quantitative manner.
Currently, we are focused on developing high-throughput experimental methods and analytic tools for a deeper understanding of the quantitative nature of post-transcriptional gene regulation. For example, our new tool, poreplex, based on nanopore direct RNA sequencing enables real-time direct measurement of poly(A) tail lengths with the complete information about the alternative splicing and alternative polyadenylation in biologically perturbed conditions (see Research). Our new technologies are expected to reveal the novel molecular phenomena that had been vastly undetectable using the existing techniques.
We are looking for new graduate students and postdocs to enjoy our explorations together (more info)!
Our group is currently based on fundings from the Center for RNA Research in the Institute for Basic Science (IBS) and the Excellent Young Researcher program of the National Research Foundation of Korea.
We have published two papers describing the detailed procedure to analyze viral transcriptomes and its application to human cytomegalovirus (HCMV) long noncoding RNAs.Nov 5, 2022
Ari received a scholarship from the Wooduk Foundation's Future Scholarship program.Jul 14, 2022
Hyeshiks explains why computer scientists should be interested in biology in the Samsung Software Developer Conference 2021.Feb 17, 2021
Hyeshik tells the human genome sequencing story to middle and high school students on the SNU/KAOS Science Open Lecture.Sep 23, 2020
The lab introduction is published as a part of the POKAS-on webzine.Aug 25, 2020
Hyeshik uploaded a YouTube video about the molecular biology of SARS-CoV-2.Mar 15, 2020
We uploaded a preprint reporting a cluster of RNA modifications in the SARS-CoV-2 RNAs.